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Issue 43, 2010
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Identification of epigenetic DNA modifications with a protein nanopore

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Abstract

Two DNA bases, 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (hmC), marks of epigenetic modification, are recognized in immobilized DNA strands and distinguished from G, A, T and C by nanopore current recording. Therefore, if further aspects of nanopore sequencing can be addressed, the approach will provide a means to locate epigenetic modifications in unamplified genomic DNA.

Graphical abstract: Identification of epigenetic DNA modifications with a protein nanopore

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Publication details

The article was received on 28 Jul 2010, accepted on 24 Sep 2010 and first published on 06 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC02864A
Citation: Chem. Commun., 2010,46, 8195-8197
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    Identification of epigenetic DNA modifications with a protein nanopore

    E. V. B. Wallace, D. Stoddart, A. J. Heron, E. Mikhailova, G. Maglia, T. J. Donohoe and H. Bayley, Chem. Commun., 2010, 46, 8195
    DOI: 10.1039/C0CC02864A

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