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Issue 40, 2010
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Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 proteinpeptide interactions

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Abstract

We report the first example of peptideprotein heteronuclear two-dimensional (2D) saturation transfer difference nuclear magnetic resonance (STD NMR). This method, resulting in dramatically reduced overlap, was applied to the interaction of the integrin αvβ6 with a known peptide ligand and highlights novel contact points between the substrate and target protein.

Graphical abstract: Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein–peptide interactions

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Publication details

The article was received on 11 Jun 2010, accepted on 24 Aug 2010 and first published on 13 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC01846E
Citation: Chem. Commun., 2010,46, 7533-7535
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    Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 proteinpeptide interactions

    J. L. Wagstaff, S. Vallath, J. F. Marshall, R. A. Williamson and M. J. Howard, Chem. Commun., 2010, 46, 7533
    DOI: 10.1039/C0CC01846E

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