Issue 40, 2010

Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6protein–peptide interactions

Abstract

We report the first example of peptideprotein heteronuclear two-dimensional (2D) saturation transfer difference nuclear magnetic resonance (STD NMR). This method, resulting in dramatically reduced overlap, was applied to the interaction of the integrin αvβ6 with a known peptide ligand and highlights novel contact points between the substrate and target protein.

Graphical abstract: Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein–peptide interactions

Supplementary files

Article information

Article type
Communication
Submitted
11 Jun 2010
Accepted
24 Aug 2010
First published
13 Sep 2010

Chem. Commun., 2010,46, 7533-7535

Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 proteinpeptide interactions

J. L. Wagstaff, S. Vallath, J. F. Marshall, R. A. Williamson and M. J. Howard, Chem. Commun., 2010, 46, 7533 DOI: 10.1039/C0CC01846E

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