Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein–peptide interactions

Jane L. Wagstaff; Sabari Vallath; John F. Marshall; Richard A. Williamson; Mark J. Howard

doi:10.1039/C0CC01846E

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Chemical Communications

Issue 40, 2010

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Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein–peptide interactions

Jane L. Wagstaff , Sabari Vallath , John F. Marshall , Richard A. Williamson and Mark J. Howard

Chem. Commun., 2010,46, 7533-7535

DOI: 10.1039/C0CC01846E
Received 11 Jun 2010, Accepted 24 Aug 2010
First published on the web 13 Sep 2010

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Abstract
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We report the first example of peptide–protein heteronuclear two-dimensional (2D) saturation transfer difference nuclear magnetic resonance (STD NMR). This method, resulting in dramatically reduced overlap, was applied to the interaction of the integrin αvβ6 with a known peptide ligand and highlights novel contact points between the substrate and target protein.