Issue 29, 2010

Formation of a cyclic tetrapeptide mimic by thermal azide–alkyne1,3-dipolar cycloaddition

Abstract

Cyclodimerisation of an appropriate α,ω-difunctionalised precursor via thermal azidealkyne 1,3-dipolar cycloaddition affords a cyclic pseudotetrapeptide whose conformation closely resembles that of a previously prepared analogue containing L-proline and 6-aminopicolinic acid subunits.

Graphical abstract: Formation of a cyclic tetrapeptide mimic by thermal azide–alkyne 1,3-dipolar cycloaddition

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2010
Accepted
21 May 2010
First published
11 Jun 2010

Chem. Commun., 2010,46, 5307-5309

Formation of a cyclic tetrapeptide mimic by thermal azidealkyne 1,3-dipolar cycloaddition

M. R. Krause, R. Goddard and S. Kubik, Chem. Commun., 2010, 46, 5307 DOI: 10.1039/C0CC01154A

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