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Issue 27, 2010
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Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs)

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Abstract

Oligonucleotides modified with pyrene-functionalized triazole-linked 2′-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.

Graphical abstract: Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs)

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Publication details

The article was received on 27 Apr 2010, accepted on 18 May 2010 and first published on 04 Jun 2010


Article type: Communication
DOI: 10.1039/C0CC01133A
Citation: Chem. Commun., 2010,46, 4929-4931
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    Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs)

    M. E. Østergaard, D. C. Guenther, P. Kumar, B. Baral, L. Deobald, A. J. Paszczynski, P. K. Sharma and P. J. Hrdlicka, Chem. Commun., 2010, 46, 4929
    DOI: 10.1039/C0CC01133A

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