Issue 27, 2010
From the journal:

Chemical Communications

Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs)†

Michael E. Østergaard,a   Dale C. Guenther,a   Pawan Kumar,ab   Bharat Baral,a   Lee Deobald,c   Andrzej J. Paszczynski,c   Pawan K. Sharmab  and  Patrick J. Hrdlicka*a  

* Corresponding authors

a Dept. of Chemistry, Univ. of Idaho, Moscow, USA
E-mail: hrdlicka@uidaho.edu
Fax: +1 208-885-6173
Tel: +1 208-885-0108

b Dept. of Chemistry, Kurukshetra University, Kurukshetra 136119, India

c Environmental Biotechnology Institute, Univ. of Idaho, USA

Abstract

Oligonucleotides modified with pyrene-functionalized triazole-linked 2′-deoxyuridines display remarkable hybridization-induced increases in fluorescence emission and enable efficient fluorescent discrimination of SNPs via G-specific quenching.

Graphical abstract: Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs)

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Article information

DOI
https://doi.org/10.1039/C0CC01133A
Article type
Communication
Submitted
27 Apr 2010
Accepted
18 May 2010
First published
04 Jun 2010

Chem. Commun., 2010,46, 4929-4931

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Pyrene-functionalized triazole-linked 2′-deoxyuridines—probes for discrimination of single nucleotide polymorphisms (SNPs)

M. E. Østergaard, D. C. Guenther, P. Kumar, B. Baral, L. Deobald, A. J. Paszczynski, P. K. Sharma and P. J. Hrdlicka, Chem. Commun., 2010, 46, 4929 DOI: 10.1039/C0CC01133A

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