Issue 32, 2010
From the journal:

Chemical Communications

Selective binding and release of aspirin by an encapsulating receptor†

Thanh V. Nguyen,a   Hiroshi Yoshidaa  and  Michael S. Sherburn*a  

* Corresponding authors

a ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Research School of Chemistry, Australian National University, Canberra, Australia
E-mail: sherburn@rsc.anu.edu.au
Fax: + 61 2 6125 8114

Abstract

The selective binding of aspirin deep inside superbowl synthetic hosts is reported. Evidence for a two-point binding mode of the drug by the host is presented. Both the strength of aspirin binding and the rate of its release are manipulated by altering the substituents about the host's aperture.

Graphical abstract: Selective binding and release of aspirin by an encapsulating receptor

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Article information

DOI
https://doi.org/10.1039/C0CC00422G
Article type
Communication
Submitted
16 Mar 2010
Accepted
08 Jun 2010
First published
05 Jul 2010

Chem. Commun., 2010,46, 5921-5923

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Selective binding and release of aspirin by an encapsulating receptor

T. V. Nguyen, H. Yoshida and M. S. Sherburn, Chem. Commun., 2010, 46, 5921 DOI: 10.1039/C0CC00422G

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