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Issue 26, 2010
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Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

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Abstract

The reactions of 6-cyano-1,3-dimethyluracil have been studied as chemical models to illustrate the mechanism for the transformation of 6-cyanouridine 5′-monophosphate (6-CN-UMP) to barbiturate ribonucleoside 5′-monophosphate (BMP) catalyzed by orotidine 5′-monophosphate decarboxylase (ODCase). The results suggest that the Asp residue in the ODCase active site plays the role of a general base in the transformation.

Graphical abstract: Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

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Publication details

The article was received on 27 Jan 2010, accepted on 21 Apr 2010 and first published on 25 May 2010


Article type: Communication
DOI: 10.1039/C001865A
Citation: Chem. Commun., 2010,46, 4821-4823
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    Chemical models and their mechanistic implications for the transformation of 6-cyanouridine 5′-monophosphate catalyzed by orotidine 5′-monophosphate decarboxylase

    Y. Wu, C. Liao, C. Jen, Y. Shih and T. Chien, Chem. Commun., 2010, 46, 4821
    DOI: 10.1039/C001865A

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