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Issue 9, 2010
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Enhanced anticancer activity of multi-walled carbon nanotubemethotrexate conjugates using cleavable linkers

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Abstract

Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.

Graphical abstract: Enhanced anticancer activity of multi-walled carbon nanotube–methotrexate conjugates using cleavable linkers

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Publication details

The article was received on 11 Nov 2009, accepted on 10 Dec 2009 and first published on 23 Dec 2009


Article type: Communication
DOI: 10.1039/B923560D
Citation: Chem. Commun., 2010,46, 1494-1496
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    Enhanced anticancer activity of multi-walled carbon nanotubemethotrexate conjugates using cleavable linkers

    C. Samorì, H. Ali-Boucetta, R. Sainz, C. Guo, F. M. Toma, C. Fabbro, T. da Ros, M. Prato, K. Kostarelos and A. Bianco, Chem. Commun., 2010, 46, 1494
    DOI: 10.1039/B923560D

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