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Issue 2, 2010
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Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

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Abstract

A hybrid library of the marine natural productsdictyostatin and discodermolide, incorporating the taxol or taxotere side chains, were synthesised; preliminary biological evaluation in the PANC-1 cancer cell line revealed significant antiproliferative activity, demonstrating that a macrolide scaffold is an effective surrogate for the baccatin core of taxol.

Graphical abstract: Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

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Publication details

The article was received on 13 Oct 2009, accepted on 10 Nov 2009 and first published on 24 Nov 2009


Article type: Communication
DOI: 10.1039/B921237J
Citation: Chem. Commun., 2010,46, 261-263
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    Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

    I. Paterson, G. J. Naylor, T. Fujita, E. Guzmán and A. E. Wright, Chem. Commun., 2010, 46, 261
    DOI: 10.1039/B921237J

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