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Issue 1, 2010
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Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

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Abstract

A strained aza-dibenzocyclooctyne was prepared via a high-yielding synthetic route. Copper-free, strain-promoted click reaction with azides showed excellent kinetics, and a functionalised aza-cyclooctyne was applied in fast and efficient PEGylation of enzymes.

Graphical abstract: Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

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Publication details

The article was received on 01 Sep 2009, accepted on 22 Oct 2009 and first published on 06 Nov 2009


Article type: Communication
DOI: 10.1039/B917797C
Citation: Chem. Commun., 2010,46, 97-99
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    Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

    M. F. Debets, S. S. van Berkel, S. Schoffelen, F. P. J. T. Rutjes, J. C. M. van Hest and F. L. van Delft, Chem. Commun., 2010, 46, 97
    DOI: 10.1039/B917797C

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