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Issue 1, 2010
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Bioluminescent nanosensors for protease detection based upon gold nanoparticle–luciferase conjugates

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Abstract

This communication reports the use of click chemistry to site-specifically conjugate bioluminescent Renilla luciferase proteins to gold nanoparticles (Au NPs) for sensing protease activity. The bioluminescent emission from luciferase was efficiently quenched by Au NPs, but significantly recovered after the proteolytic cleavage.

Graphical abstract: Bioluminescent nanosensors for protease detection based upon gold nanoparticle–luciferase conjugates

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Publication details

The article was received on 30 Jul 2009, accepted on 28 Sep 2009 and first published on 12 Oct 2009


Article type: Communication
DOI: 10.1039/B915612G
Citation: Chem. Commun., 2010,46, 76-78
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    Bioluminescent nanosensors for protease detection based upon gold nanoparticle–luciferase conjugates

    Y. Kim, W. L. Daniel, Z. Xia, H. Xie, C. A. Mirkin and J. Rao, Chem. Commun., 2010, 46, 76
    DOI: 10.1039/B915612G

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