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Issue 12, 2010
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One-pot preparation of dextran-capped gold nanoparticles at room temperature and colorimetric detection of dihydralazine sulfate in uric samples

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Abstract

We present a room-temperature strategy for the preparation of dextran-capped gold nanoparticles (AuNPs) in this contribution by employing dextran, which acts as both a reducing agent and a stabilizer, and thus well dispersed, uniform and biocompatible AuNPs could be successfully prepared in one pot. The investigations, including toxicological effect on cells and the capability of resisting aggregation in high ion medium, have demonstrated that the as-prepared AuNPs are biocompatible and stable even if in a medium of high ionic strength. In order to identify the practicability of the dextran-capped AuNPs, colorimetric detection of dihydralazine sulfate (DHZS) in uric samples based on the localized surface plasmon resonance (LSPR) of the AuNPs is made with the recovery in the range of 98.3–102.5%.

Graphical abstract: One-pot preparation of dextran-capped gold nanoparticles at room temperature and colorimetric detection of dihydralazine sulfate in uric samples

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Publication details

The article was received on 28 Jul 2010, accepted on 16 Sep 2010 and first published on 13 Oct 2010


Article type: Paper
DOI: 10.1039/C0AY00470G
Citation: Anal. Methods, 2010,2, 1982-1988
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    One-pot preparation of dextran-capped gold nanoparticles at room temperature and colorimetric detection of dihydralazine sulfate in uric samples

    Y. Wang, L. Zhan and C. Z. Huang, Anal. Methods, 2010, 2, 1982
    DOI: 10.1039/C0AY00470G

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