Issue 7, 2010

An in vitrocrystallization setup to assess the efficiency of different phosphate binders in nephrology: quantitative analytical considerations

Abstract

An increased phosphate level in the blood (hyperphosphatemia) is a severe problem for dialysis patients. Different phosphate binders which are used to prevent hyperphosphatemia were studied in a custom-made in vitro crystallization apparatus which simulated the stomach (pH 2) and the gut (pH 7). The effective phosphate binding capacity was measured and the resulting products were identified. This apparatus permits the quantitative analysis of the phosphate binding effect under the given in vitro conditions. In particular, phosphate binders on the basis of calcium acetate (Calciumacetat Nefro®), calcium carbonate (Calciumcarbonat® Fresenius), aluminium hydroxide (Antiphosphat®), lanthanum carbonate (Fosrenol®), and poly(allylamine hydrochloride) (Renagel®) were studied, and also compared with pure calcium acetate, calcium carbonate, and aluminium sulfate.

Graphical abstract: An in vitro crystallization setup to assess the efficiency of different phosphate binders in nephrology: quantitative analytical considerations

Article information

Article type
Paper
Submitted
27 Dec 2009
Accepted
24 Apr 2010
First published
19 May 2010

Anal. Methods, 2010,2, 901-911

An in vitro crystallization setup to assess the efficiency of different phosphate binders in nephrology: quantitative analytical considerations

T. Peitsch, M. Matthes, V. Brandenburg and M. Epple, Anal. Methods, 2010, 2, 901 DOI: 10.1039/B9AY00325H

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