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Issue 12, 2010
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Evaluation of Raman probe for oesophageal cancer diagnostics

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Early detection of (pre-)cancerous changes improves prognosis, therefore in the UK patients at high risk of developing gastrointestinal cancers are enrolled on endoscopic surveillance programmes or the Bowel Cancer Screening Programme. The current gold standard technique for the detection of pre-cancerous changes in the gastrointestinal tract is histopathological analysis of biopsy tissue collected at endoscopy. This relies upon subjective assessment of morphological changes within the excised tissue samples and poor targeting of pre-malignant lesions. Raman spectroscopy offers a number of potential advantages for in vivo assessment of tissue at endoscopy. The performance of a custom built Raman probe as a biopsy targeting tool has been evaluated using excised biopsy material. Multivariate classification models have been used to demonstrate the likely ability of a miniature, confocal, fibre optic Raman probe to be used as an optical biopsy tool at endoscopy to provide spectral information in clinically practicable timescales. This technique could facilitate improved targeting of excisional biopsy with associated clinical benefits.

Graphical abstract: Evaluation of Raman probe for oesophageal cancer diagnostics

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Publication details

The article was received on 16 Jul 2010, accepted on 14 Sep 2010 and first published on 15 Oct 2010

Article type: Paper
DOI: 10.1039/C0AN00536C
Citation: Analyst, 2010,135, 3038-3041
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    Evaluation of Raman probe for oesophageal cancer diagnostics

    C. Kendall, J. Day, J. Hutchings, B. Smith, N. Shepherd, H. Barr and N. Stone, Analyst, 2010, 135, 3038
    DOI: 10.1039/C0AN00536C

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