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Issue 9, 2010
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Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry

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Abstract

Nanospray desorption electrospray ionization (nano-DESI) mass spectrometry is presented as an ambient pressure liquid extraction-ionization technique for analysis of organic and biological molecules on substrates. Analyte is desorbed into a solvent bridge formed between two capillaries and the analysis surface. One capillary supplies solvent to create and maintain the bridge, while the second capillary transports the dissolved analyte from the bridge to the mass spectrometer. A high voltage applied between the inlet of mass spectrometer and the primary capillary creates a self-aspirating nanospray. This approach enables the separation of desorption and ionization events, thus providing independent control of desorption, ionization, and transport of the analyte. We present analytical capabilities of the method and discuss its potential for imaging applications.

Graphical abstract: Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry

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Publication details

The article was received on 14 May 2010, accepted on 17 Jun 2010 and first published on 30 Jun 2010


Article type: Communication
DOI: 10.1039/C0AN00312C
Citation: Analyst, 2010,135, 2233-2236
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    Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry

    P. J. Roach, J. Laskin and A. Laskin, Analyst, 2010, 135, 2233
    DOI: 10.1039/C0AN00312C

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