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Issue 4, 2010
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Desorption electrospray ionization and other ambient ionization methods: current progress and preview

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Abstract

Mass spectrometry allows rapid chemical analysis of untreated samples in the ambient environment. This is a result of recent rapid progress in ambient ionization techniques. The most widely studied of these new methods, desorption electrospray ionization (DESI), uses fast-moving solvent droplets to extract analytes from surfaces and propel the resulting secondary microdroplets towards the mass analyzer. This review of DESI and other ambient methods centers on the accompanying chemical processes. Manipulation of the chemistry accompanying ambient ionization can be used to optimize chemical analysis, including molecular imaging. Solvent effects, geometry effects, electrochemical processes and mechanisms are covered. Extensions of the methodology to solution-phase analysis, to stand-off detection and to therapeutic drug analysis using miniature mass spectrometers are also treated.

Graphical abstract: Desorption electrospray ionization and other ambient ionization methods: current progress and preview

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Publication details

The article was received on 01 Dec 2009, accepted on 16 Feb 2010 and first published on 02 Mar 2010


Article type: Critical Review
DOI: 10.1039/B925257F
Citation: Analyst, 2010,135, 669-681
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    Desorption electrospray ionization and other ambient ionization methods: current progress and preview

    D. R. Ifa, C. Wu, Z. Ouyang and R. G. Cooks, Analyst, 2010, 135, 669
    DOI: 10.1039/B925257F

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