An investigation of the RWPE prostate derived family of cell lines using FTIR spectroscopy

M. J. Baker; C. Clarke; D. Démoulin; J. M. Nicholson; F. M. Lyng; H. J. Byrne; C. A. Hart; M. D. Brown; N. W. Clarke; P. Gardner

doi:10.1039/B920385K

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Analyst

Issue 5, 2010

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An investigation of the RWPE prostate derived family of cell lines using FTIR spectroscopy

M. J. Baker,^a C. Clarke,^b D. Démoulin,^a J. M. Nicholson,^f F. M. Lyng,^b H. J. Byrne,^b C. A. Hart,^c M. D. Brown,^c N. W. Clarke^c^d^e and P. Gardner*^a

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Manchester Interdisciplinary Biocentre, Centre for Instrumentation and Analytical Science, School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester, UK
E-mail: peter.gardner@manchester.ac.uk ;
Tel: +44 (0)161 306 4463

FOCAS Research Institute, Dublin Institute of Technology, Kevin Street, Dublin, Ireland

Genito Urinary Cancer Research Group, School of Cancer, Enabling Science and Technology, Paterson Institute for Cancer Research, University of Manchester, Manchester Academic Health Science Centre, The Christie NHS Foundation Trust, Manchester, UK

Department of Urology, The Christie NHS Foundation Trust, Manchester, UK

Department of Urology, Salford Royal NHS Foundation Trust, Salford, UK

STFC Daresbury Laboratory, Daresbury, Warrington, UK

Analyst, 2010,135, 887-894

DOI: 10.1039/B920385K
Received 30 Sep 2009, Accepted 10 Feb 2010
First published online 04 Mar 2010

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Interest in developing robust, quicker and easier diagnostic tests for cancer has lead to an increased use of Fourier transform infrared (FTIR) spectroscopy to meet that need. In this study we present the use of different experimental modes of infrared spectroscopy to investigate the RWPE human prostate epithelial cell line family which are derived from the same source but differ in their mode of transformation and their mode of invasive phenotype. Importantly, analysis of the infrared spectra obtained using different experimental modes of infrared spectroscopy produces similar results. The RWPE family of cell lines can be separated into groups based upon the method of cell transformation rather than the resulting invasiveness/aggressiveness of the cell line. The study also demonstrates the possibility of using a genetic algorithm as a possible standardised pre-processing step and raises the important question of the usefulness of cell lines to create a biochemical model of prostate cancer progression.

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