Designing microfluidic channel that separates elastic particles upon stiffness

John P. Arata; Alexander Alexeev

doi:10.1039/B908213A

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Soft Matter

Issue 14, 2009

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Designing microfluidic channel that separates elastic particles upon stiffness

John P. Arata and Alexander Alexeev

Soft Matter, 2009, 5, 2721-2724

DOI: 10.1039/B908213A
Received 30 Apr 2009, Accepted 27 May 2009
First published on the web 09 Jun 2009

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Using three-dimensional computer simulations, we model the movement of soft, elastic particles in microfluidic channels with periodic constrictions formed by diagonal solid ridges. Our simulations reveal that when the gap between ridges is smaller than the particle diameter, particles with dissimilar compliance follow distinct paths and segregate to opposite sides of the microchannel. This simple microfluidic method can be useful for continuous stiffness-based sorting and separation of biological cells and synthetic microcapsules.

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