Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

Leon M. Bellan; Sunil P. Singh; Peter W. Henderson; Teresa J. Porri; Harold G. Craighead; Jason A. Spector

doi:10.1039/B819905A

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Soft Matter

Issue 7, 2009

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Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

Leon M. Bellan , Sunil P. Singh , Peter W. Henderson , Teresa J. Porri , Harold G. Craighead and Jason A. Spector

Soft Matter, 2009, 5, 1354-1357

DOI: 10.1039/B819905A
Received 07 Nov 2008, Accepted 23 Jan 2009
First published on the web 09 Feb 2009

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Abstract
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Compounds
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Using sacrificial sugar structures, we have formed a 3D fluidic vascular network in a polymeric matrix. Melt-spun sugar fibers (cotton candy) were used to form channels with diameters and densities similar to those of capillaries. To interface to macroscopic fluidic systems, larger sacrificial sugar structures were used to form an artificial inlet and outlet. To verify that the channel network supported flow, we used video fluorescence microscopy to image both 2 µm fluorescent polystyrene spheres in an aqueous solution and fluorescently labeled blood. This fabrication process may be applied to a wide range of polymeric materials and is rapid, inexpensive, and highly scalable.

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Supplementary Info

Figure S1: demonstration of blood filling a PDMS construct
PDF (124K)
Video 1: multiphoton microscopy data of a PDMS construct filled with dye
MPG (5262K)
Video 2: fluorescent polystyrene spheres flowing in a PDMS construct
MPG (30549K)
Video 3: fluorescently labled whole rat blood flowing in a PDMS construct
MPG (30684K)
Detailed description of sugar structure fabrication
PDF (81K)

Articles By

Leon M. Bellan
Sunil P. Singh
Peter W. Henderson
Teresa J. Porri
Harold G. Craighead
Jason A. Spector

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Soft Matter

Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

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