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Issue 7, 2009
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Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

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Abstract

Using sacrificial sugar structures, we have formed a 3D fluidic vascular network in a polymeric matrix. Melt-spun sugar fibers (cotton candy) were used to form channels with diameters and densities similar to those of capillaries. To interface to macroscopic fluidic systems, larger sacrificial sugar structures were used to form an artificial inlet and outlet. To verify that the channel network supported flow, we used video fluorescence microscopy to image both 2 µm fluorescent polystyrene spheres in an aqueous solution and fluorescently labeled blood. This fabrication process may be applied to a wide range of polymeric materials and is rapid, inexpensive, and highly scalable.

Graphical abstract: Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

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Publication details

The article was received on 07 Nov 2008, accepted on 23 Jan 2009 and first published on 09 Feb 2009


Article type: Communication
DOI: 10.1039/B819905A
Citation: Soft Matter, 2009,5, 1354-1357
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    Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures

    L. M. Bellan, S. P. Singh, P. W. Henderson, T. J. Porri, H. G. Craighead and J. A. Spector, Soft Matter, 2009, 5, 1354
    DOI: 10.1039/B819905A

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