Issue 3, 2009
From the journal:

Soft Matter

pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media†

Akihiro Kishimura,a   Sittipong Liamsuwan,b   Hiroyuki Matsuda,b   Wen-Fei Dong,a   Kensuke Osada,a   Yuichi Yamasakia  and  Kazunori Kataoka*abcd  

* Corresponding authors

a Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: kataoka@bmw.t.u-tokyo.ac.jp
Fax: +81-3-5841-7139
Tel: +81-3-5841-7138

b Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

c Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

d Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

Abstract

The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.

Graphical abstract: pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

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Article information

DOI
https://doi.org/10.1039/B815884C
Article type
Communication
Submitted
12 Sep 2008
Accepted
11 Nov 2008
First published
28 Nov 2008

Soft Matter, 2009,5, 529-532

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pH-dependent permeability change and reversible structural transition of PEGylated polyion complex vesicles (PICsomes) in aqueous media

A. Kishimura, S. Liamsuwan, H. Matsuda, W. Dong, K. Osada, Y. Yamasaki and K. Kataoka, Soft Matter, 2009, 5, 529 DOI: 10.1039/B815884C

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