Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 1, 2009
Previous Article Next Article

Asymmetric lipid bilayer sandwiched in polyelectrolyte multilayer films through layer-by-layer assembly

Author affiliations

Abstract

Lipid bilayer of 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine (DMPE) was formed on the surface of a linearly growing polyanion/polycation polyelectrolyte multilayer (PEM) film prepared by the layer-by-layer (LbL) technique. The PEM films were prepared with two strong polyelectrolytes—poly(sodium 4-styrenesulfonate) (PSS) as the polyanion and poly-(diallyldimethylammonium chloride) (PDADMAC) as the polycation. The DMPE was always deposited onto the PEM cushion terminated with positively charged PDADMAC. The surface charge of the DMPE-coated film depends on the pH of the buffer solution. Formation of PEM could be continued on the top of the lipid bilayer by tuning the headgroup charge of the DMPE. An asymmetric structure of polycation/lipid/polyanion “sandwich” was created in the case where anionic PSS was used as the first layer of the subsequent PEM. In this system, the DMPE lipid membrane was constructed as a charge asymmetric barrier sandwiched in the interior of the PEM films. The formation of PEM architectures incorporated with an asymmetric DMPE bilayer was confirmed by ζ potential, UV-vis absorption, quartz crystal microbalance (QCM) and neutron reflectometry experiments.

Graphical abstract: Asymmetric lipid bilayer sandwiched in polyelectrolyte multilayer films through layer-by-layer assembly

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 21 May 2008, accepted on 18 Aug 2008 and first published on 16 Oct 2008


Article type: Paper
DOI: 10.1039/B808572B
Citation: Soft Matter, 2009,5, 228-233
  •   Request permissions

    Asymmetric lipid bilayer sandwiched in polyelectrolyte multilayer films through layer-by-layer assembly

    J. Chen, R. Köhler, T. Gutberlet, H. Möhwald and R. Krastev, Soft Matter, 2009, 5, 228
    DOI: 10.1039/B808572B

Search articles by author