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Issue 1, 2009
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Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

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Abstract

Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.

Graphical abstract: Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

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Publication details

The article was received on 27 Jun 2008, accepted on 09 Oct 2008 and first published on 28 Oct 2008


Article type: Paper
DOI: 10.1039/B810921D
Citation: Photochem. Photobiol. Sci., 2009,8, 37-44
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    Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

    M. I. Burguete, F. Galindo, R. Gavara, S. V. Luis, M. Moreno, P. Thomas and D. A. Russell, Photochem. Photobiol. Sci., 2009, 8, 37
    DOI: 10.1039/B810921D

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