Issue 1, 2009
From the journal:

Photochemical & Photobiological Sciences

Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells†

M. Isabel Burguete,a   Francisco Galindo,*a   Raquel Gavara,a   Santiago V. Luis,*a   Miguel Moreno,b   Paul Thomasc  and  David A. Russell*b  

* Corresponding authors

a Departamento de Química Inorgánica y Orgánica/UAMOA; Universitat Jaume I/CSIC; Av. Sos Baynat, s/n, Castellón, Spain
E-mail: francisco.galindo@uji.es, luiss@uji.es

b School of Chemical Sciences and Pharmacy, University of East Anglia, Norfolk, Norwich, UK
E-mail: D.Russell@uea.ac.uk

c School of Biological Sciences, University of East Anglia, Norfolk, Norwich, UK

Abstract

Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.

Graphical abstract: Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B810921D
Article type
Paper
Submitted
27 Jun 2008
Accepted
09 Oct 2008
First published
28 Oct 2008

Photochem. Photobiol. Sci., 2009,8, 37-44

Permissions

Request permissions

Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells

M. I. Burguete, F. Galindo, R. Gavara, S. V. Luis, M. Moreno, P. Thomas and D. A. Russell, Photochem. Photobiol. Sci., 2009, 8, 37 DOI: 10.1039/B810921D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements