Clickable fluorescent dyes for multimodal bioorthogonal imaging

Lun K. Tsou; Mingzi M. Zhang; Howard C. Hang

doi:10.1039/B917119N

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Organic & Biomolecular Chemistry

Issue 24, 2009

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Clickable fluorescent dyes for multimodal bioorthogonal imaging

Lun K. Tsou , Mingzi M. Zhang and Howard C. Hang

Org. Biomol. Chem., 2009, 7, 5055-5058

DOI: 10.1039/B917119N
Received 18 Aug 2009, Accepted 18 Sep 2009
First published on the web 26 Oct 2009
This article is part of the collection: Protein Labelling and Chemical Proteomics

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Abstract
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Compounds
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Bioorthogonal ligation with functionalized fluorescent dyes enables visualization of nuclei acids, proteins and metabolites in biological systems. Bright and modular azide- and alkyne-functionalized dyes are therefore needed to expand the fluorescence imaging capabilities of bioorthogonal ligation methods. We describe the concise synthesis of clickable fluorescent dyes based on 2-dicyanomethylene-3-cyano-2,5-dihydrofuran fluorophores and demonstrate their utility for multicolor imaging of azide- and alkyne-modified proteins as well as FRET studies.

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Supplementary Info

Synthetic methods and supplementary figures (Fig.S1–Fig. S4)
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Organic & Biomolecular Chemistry

Clickable fluorescent dyes for multimodal bioorthogonal imaging

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