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Issue 22, 2009
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Efficient synthesis of the C7-C20 subunit of amphidinolides C and F

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Abstract

Synthesis of the C7-C20 subunit of amphidinolides C and F has been accomplished utilizing a Me3Al-mediated ring opening of a vinyl iodide/allylic epoxide to establish the C12,13anti stereochemistry, an organolithium coupling/olefination sequence to construct the C9-C11 diene moiety and a sulfone alkylation/hydroxylation strategy to join the C7-C14 and C15-C20 fragments.

Graphical abstract: Efficient synthesis of the C7-C20 subunit of amphidinolides C and F

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Publication details

The article was received on 13 Aug 2009, accepted on 07 Sep 2009 and first published on 16 Sep 2009


Article type: Communication
DOI: 10.1039/B916744G
Citation: Org. Biomol. Chem., 2009,7, 4582-4585
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    Efficient synthesis of the C7-C20 subunit of amphidinolides C and F

    S. Mahapatra and R. G. Carter, Org. Biomol. Chem., 2009, 7, 4582
    DOI: 10.1039/B916744G

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