Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

Michael P. Van Ryssen; Nicolaos Avlonitis; Rashid Giniatullin; Craig McDougall; James L. Carr; Megan N. Stanton-Humphreys; Emma L. A. Borgström; C. Tom A. Brown; Dmitriy Fayuk; Alexander Surin; Minna Niittykoski; Leonard Khiroug; Stuart J. Conway

doi:10.1039/B914981C

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Organic & Biomolecular Chemistry

Issue 22, 2009

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Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

Michael P. Van Ryssen , Nicolaos Avlonitis , Rashid Giniatullin , Craig McDougall , James L. Carr , Megan N. Stanton-Humphreys , Emma L. A. Borgström , C. Tom A. Brown , Dmitriy Fayuk , Alexander Surin , Minna Niittykoski , Leonard Khiroug and Stuart J. Conway

Org. Biomol. Chem., 2009, 7, 4695-4707

DOI: 10.1039/B914981C
Received 23 Jul 2009, Accepted 24 Aug 2009
First published on the web 24 Sep 2009

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The synthesis of a range of caged TRPV1 agonists and antagonists is reported. The photolysis characteristics of these compounds, when irradiated with a 355 nm laser, have been studied and in all cases the desired compound was produced. Photolysis of a caged TRPV1 agonist in cultured trigeminal neurons produced responses that were consistent with the activation of TRPV1 receptors.

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Organic & Biomolecular Chemistry

Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

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