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Issue 23, 2009
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Peptide thioester synthesis through N→S acyl-transfer: application to the synthesis of a β-defensin

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Abstract

Peptide thioesters readily prepared through N→S acyl transfer of a specific C-terminal motif provide access to biologically active mini-proteins using native chemical ligation.

Graphical abstract: Peptide thioester synthesis through N→S acyl-transfer: application to the synthesis of a β-defensin

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Publication details

The article was received on 13 Jul 2009, accepted on 01 Sep 2009 and first published on 24 Sep 2009


Article type: Paper
DOI: 10.1039/B913886B
Citation: Org. Biomol. Chem., 2009,7, 4918-4923
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    Peptide thioester synthesis through N→S acyl-transfer: application to the synthesis of a β-defensin

    J. Kang, N. L. Reynolds, C. Tyrrell, J. R. Dorin and D. Macmillan, Org. Biomol. Chem., 2009, 7, 4918
    DOI: 10.1039/B913886B

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