1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents

Carmen Nájera; José M. Sansano

doi:10.1039/B913066G

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Organic & Biomolecular Chemistry

Issue 22, 2009

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1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents

Carmen Nájera and José M. Sansano

Org. Biomol. Chem., 2009, 7, 4567-4581

DOI: 10.1039/B913066G
Received 01 Jul 2009, First published on the web 01 Oct 2009

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In the present perspective the advances and real possibilities of 1,3-dipolar cycloadditions as key steps in the total synthesis of virus inhibitors are described. Azides, nitrones, and azomethine ylides are the most appropriate 1,3-dipoles for the synthesis of privileged structures with the highest biological responses against viruses.

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Organic & Biomolecular Chemistry

1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents

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