Homophymines B–E and A1–E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

Angela Zampella; Valentina Sepe; Filomena Bellotta; Paolo Luciano; Maria Valeria D'Auria; Thierry Cresteil; Cécile Debitus; Sylvain Petek; Christiane Poupat; Alain Ahond

doi:10.1039/B910015F

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Organic & Biomolecular Chemistry

Issue 19, 2009

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Homophymines B–E and A1–E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

Angela Zampella , Valentina Sepe , Filomena Bellotta , Paolo Luciano , Maria Valeria D'Auria , Thierry Cresteil , Cécile Debitus , Sylvain Petek , Christiane Poupat and Alain Ahond

Org. Biomol. Chem., 2009, 7, 4037-4044

DOI: 10.1039/B910015F
Received 21 May 2009, Accepted 23 Jun 2009
First published on the web 22 Jul 2009

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Nine new cyclodepsipeptides, homophymines B–E (2–5) and A1–E1 (1a–5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC₅₀ in the nM range) against a panel of human cancer cell lines.

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Organic & Biomolecular Chemistry

Homophymines B–E and A1–E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

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