Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents

Susanne Mecklenburg; Saad Shaaban; Lalla A. Ba; Torsten Burkholz; Thomas Schneider; Britta Diesel; Alexandra K. Kiemer; Anne Röseler; Katja Becker; Jörg Reichrath; Alexandra Stark; Wolfgang Tilgen; Muhammad Abbas; Ludger A. Wessjohann; Florenz Sasse; Claus Jacob

doi:10.1039/B907831B

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Organic & Biomolecular Chemistry

Issue 22, 2009

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Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents

Susanne Mecklenburg , Saad Shaaban , Lalla A. Ba , Torsten Burkholz , Thomas Schneider , Britta Diesel , Alexandra K. Kiemer , Anne Röseler , Katja Becker , Jörg Reichrath , Alexandra Stark , Wolfgang Tilgen , Muhammad Abbas , Ludger A. Wessjohann , Florenz Sasse and Claus Jacob

Org. Biomol. Chem., 2009, 7, 4753-4762

DOI: 10.1039/B907831B
Received 20 Apr 2009, Accepted 03 Aug 2009
First published on the web 11 Sep 2009

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Various human illnesses, including several types of cancer and infectious diseases, are related to changes in the cellular redox homeostasis. During the last decade, several approaches have been explored which employ such disturbed redox balances for the benefit of therapy. Compounds able to modulate the intracellular redox state of cells have been developed, which effectively, yet also selectively, appear to kill cancer cells and a range of pathogenic microorganisms. Among the various agents employed, certain redox catalysts have shown considerable promise since they are non-toxic on their own yet develop an effective, often selective cytotoxicity in the presence of the ‘correct’ intracellular redox partners. Aminoalkylation, amide coupling and multicomponent reactions are suitable synthetic methods to generate a vast number of such multifunctional catalysts, which are chemically diverse and, depending on their structure, exhibit various interesting biological activities.

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Organic & Biomolecular Chemistry

Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents

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