Issue 21, 2009
From the journal:

Organic & Biomolecular Chemistry

An efficient method for the preparation of peptide alcohols†

Alan Roy Katritzky,*a   Nader Elmaghwry Abo-Dya,ab   Srinivasa Rao Tala,a   Kapil Gyandaa  and  Zakaria Kamel Abdel-Samiib  

* Corresponding authors

a Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
E-mail: katritzky@chem.ufl.edu
Fax: +1-352-392-9199
Tel: +1-352-392- 0554

b Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig-44519, Egypt

Abstract

N -Protected LL-dipeptide alcohols 3a–p, diastereomeric mixture (3d + 3d′) and tripeptide alcohols 6a–c were synthesized by treatment of various amino alcohols with N-protected(α-aminoacyl)benzotriazoles 1a–c, 1f–m, (1a + 1a′) and N-protected(α-dipeptidoyl)benzotriazoles 5a, 5b respectively in good yields with complete retention of chirality.

Graphical abstract: An efficient method for the preparation of peptide alcohols

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Article information

DOI
https://doi.org/10.1039/B905730G
Article type
Paper
Submitted
23 Mar 2009
Accepted
13 Jul 2009
First published
26 Aug 2009

Org. Biomol. Chem., 2009,7, 4444-4447

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An efficient method for the preparation of peptide alcohols

A. R. Katritzky, N. E. Abo-Dya, S. R. Tala, K. Gyanda and Z. K. Abdel-Samii, Org. Biomol. Chem., 2009, 7, 4444 DOI: 10.1039/B905730G

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