Jump to main content
Jump to site search

Issue 16, 2009
Previous Article Next Article

Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Author affiliations

Abstract

Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-α. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.

Graphical abstract: Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Feb 2009, accepted on 13 May 2009 and first published on 17 Jun 2009


Article type: Paper
DOI: 10.1039/B902041A
Citation: Org. Biomol. Chem., 2009,7, 3230-3235
  •   Request permissions

    Saponins as novel TNF-α inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

    B. A. Shah, R. Chib, P. Gupta, V. K. Sethi, S. Koul, S. S. Andotra, A. Nargotra, S. Sharma, A. Pandey, S. Bani, B. Purnima and S. C. Taneja, Org. Biomol. Chem., 2009, 7, 3230
    DOI: 10.1039/B902041A

Search articles by author

Spotlight

Advertisements