Issue 11, 2009
From the journal:

Organic & Biomolecular Chemistry

A general strategy for the preparation of C-terminal peptide α-ketoacids by solid phase peptide synthesis†

Lei Jua  and  Jeffrey W. Bode*a  

* Corresponding authors

a Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA
E-mail: bode@sas.upenn.edu
Tel: +1 215-573-1953

Abstract

A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide α-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide α-ketoacids with unprotected side chains is reported.

Graphical abstract: A general strategy for the preparation of C-terminal peptide α-ketoacids by solid phase peptide synthesis

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Article information

DOI
https://doi.org/10.1039/B901198F
Article type
Communication
Submitted
20 Jan 2009
Accepted
25 Mar 2009
First published
02 Apr 2009

Org. Biomol. Chem., 2009,7, 2259-2264

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A general strategy for the preparation of C-terminal peptide α-ketoacids by solid phase peptide synthesis

L. Ju and J. W. Bode, Org. Biomol. Chem., 2009, 7, 2259 DOI: 10.1039/B901198F

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