Issue 5, 2009
From the journal:

Organic & Biomolecular Chemistry

Direct C–H borylation and C–H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines†

Martin Klečka,a   Radek Pohl,a   Blanka Klepetářováa  and  Michal Hocek*a  

* Corresponding authors

a Institute of Organic Chemistry and Biochemistry, v.v.i., Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center, Flemingovo nam. 2, Prague 6, Czech Republic
E-mail: hocek@uochb.cas.cz
Fax: +420 220183559
Tel: +420 220183324

Abstract

Novel direct C–H borylations of 7-deazapurines to position 8 by B2pin2 under Ir catalysis were followed by Suzuki cross-couplings with aryl halides and other functional group transformations to give diverse 8-substituted 7-deazaadenines.

Graphical abstract: Direct C–H borylation and C–H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines

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Article information

DOI
https://doi.org/10.1039/B900218A
Article type
Communication
Submitted
06 Jan 2009
Accepted
06 Jan 2009
First published
14 Jan 2009

Org. Biomol. Chem., 2009,7, 866-868

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Direct C–H borylation and C–H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines

M. Klečka, R. Pohl, B. Klepetářová and M. Hocek, Org. Biomol. Chem., 2009, 7, 866 DOI: 10.1039/B900218A

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