Triggering cryptic natural product biosynthesis in microorganisms

Kirstin Scherlach; Christian Hertweck

doi:10.1039/B821578B

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Organic & Biomolecular Chemistry

Issue 9, 2009

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Triggering cryptic natural product biosynthesis in microorganisms

Kirstin Scherlach and Christian Hertweck

Org. Biomol. Chem., 2009, 7, 1753-1760

DOI: 10.1039/B821578B
Received 02 Dec 2008, Accepted 27 Jan 2009
First published on the web 06 Mar 2009

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Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it seems that many valuable compounds are overlooked when culturing microbes under standardized laboratory conditions. Many biosynthesis genes remain silent and such “cryptic” or “orphan” pathways are only activated under specific conditions. This report gives an overview on the strategies to trigger biosynthetic pathways to yield “cryptic natural products” through external cues, co-cultivation and genomic approaches such as genome-mining, epigenetic remodeling, and engineered pathway activation.

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Organic & Biomolecular Chemistry

Triggering cryptic natural product biosynthesis in microorganisms

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