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Issue 8, 2009
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Efficient solvent- and metal-free Sonogashira protocol catalysed by 1,4-diazabicyclo(2.2.2) octane (DABCO)

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Abstract

An efficient metal-free Sonogashira coupling protocol catalysed by DABCO is reported, where very good conversions and selectivities to the cross-coupling product were obtained under mild reaction conditions. The reported solvent-, phosphane- and metal-free protocol, that uses a cheap base as catalyst, considerably improves the green credentials of the reaction.

Graphical abstract: Efficient solvent- and metal-free Sonogashira protocol catalysed by 1,4-diazabicyclo(2.2.2) octane (DABCO)

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Publication details

The article was received on 25 Nov 2008, accepted on 12 Jan 2009 and first published on 06 Mar 2009


Article type: Paper
DOI: 10.1039/B821134P
Citation: Org. Biomol. Chem., 2009,7, 1627-1632
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    Efficient solvent- and metal-free Sonogashira protocol catalysed by 1,4-diazabicyclo(2.2.2) octane (DABCO)

    R. Luque and D. J. Macquarrie, Org. Biomol. Chem., 2009, 7, 1627
    DOI: 10.1039/B821134P

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