Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity

Teather J. Sundstrom; Amy C. Anderson; Dennis L. Wright

doi:10.1039/B819067B

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Organic & Biomolecular Chemistry

Issue 5, 2009

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Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity

Teather J. Sundstrom , Amy C. Anderson and Dennis L. Wright

Org. Biomol. Chem., 2009, 7, 840-850

DOI: 10.1039/B819067B
Received 27 Oct 2008, Accepted 24 Nov 2008
First published on the web 08 Jan 2009

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Phosphoinositide-3-kinase is a pivotal protein involved in a wide variety of signaling cascades and there has been a great deal of interest in the development of potent and selective inhibitors of this enzyme. In this review, the potency and selectivity of the known inhibitors is presented along with key structural information that helps rationalize the observed trends.

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Organic & Biomolecular Chemistry

Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity

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