Issue 6, 2009

Metal-catalysed halogen exchange reactions of aryl halides

Abstract

Aryl halides are common synthetic targets themselves, and also highly versatile synthetic intermediates. Aryl chlorides are much more widely available and easier to synthesise than the other halide derivatives, so the development of effective methods for interconverting aryl halide derivatives would therefore be extremely useful. This article outlines which transformations are particularly desirable, and describes the progress that has been made on developing methods for carrying out those transformations using copper, nickel or palladium catalysts. The possible mechanisms of these reactions are discussed, with a view to identifying areas for future investigation.

Graphical abstract: Metal-catalysed halogen exchange reactions of aryl halides

Additions and corrections

Article information

Article type
Emerging Area
Submitted
15 Oct 2008
Accepted
11 Dec 2008
First published
30 Jan 2009

Org. Biomol. Chem., 2009,7, 1043-1052

Metal-catalysed halogen exchange reactions of aryl halides

T. D. Sheppard, Org. Biomol. Chem., 2009, 7, 1043 DOI: 10.1039/B818155A

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