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Issue 8, 2009
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Structure–function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function

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Abstract

Oligomers of N-substituted glycine, or peptoids, are versatile tools to probe biological processes and hold promise as therapeutic agents. An underlying theme in the majority of recent peptoid research is the connection between peptoid function and peptoid structure. For certain applications, well-folded peptoids are essential for activity, while unstructured peptoids appear to suffice, or even are superior, for other applications. Currently, these structure–function connections are largely made after the design, synthesis, and characterization process. However, as guidelines for peptoid folding are elucidated and the known biological activities are expanded, we anticipate these connections will provide a pathway toward the de novo design of functional peptoids. In this perspective, we review several of the peptoid structure–function relationships that have been delineated over the past five years.

Graphical abstract: Structure–function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function

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Publication details

The article was received on 13 Oct 2008, accepted on 05 Jan 2009 and first published on 11 Feb 2009


Article type: Perspective
DOI: 10.1039/B817980H
Citation: Org. Biomol. Chem., 2009,7, 1508-1524
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    Structure–function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function

    S. A. Fowler and H. E. Blackwell, Org. Biomol. Chem., 2009, 7, 1508
    DOI: 10.1039/B817980H

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