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Issue 10, 2009
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Apparent non-statistical binding in a ditopic receptor for guanosine

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Abstract

Analysis of stepwise association constants for guests binding to more than one site in a receptor is expected to give a ratio of the first association constant to the second of about 4 : 1 on statistical grounds (since a second guest should have an equal chance of binding to a different site on the same, or a new molecule). Taking account of self-association in our analysis of a system in which the binding sites are close together, we observe a ratio closer to 1 : 1, indicative of non-statistical, or cooperative binding. The longer homologue built around two alkynes displays a very different ratio of stepwise association constants of about 7 : 1. We discuss the origins of this unusual behaviour in terms of steric interactions within the receptors and their corresponding complexes with guanosine derivatives.

Graphical abstract: Apparent non-statistical binding in a ditopic receptor for guanosine

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Publication details

The article was received on 28 Jul 2008, accepted on 23 Jan 2009 and first published on 24 Mar 2009


Article type: Paper
DOI: 10.1039/B812969J
Citation: Org. Biomol. Chem., 2009,7, 2093-2103
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    Apparent non-statistical binding in a ditopic receptor for guanosine

    A. Likhitsup, R. J. Deeth, S. Otto and A. Marsh, Org. Biomol. Chem., 2009, 7, 2093
    DOI: 10.1039/B812969J

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