Issue 3, 2009

A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

Abstract

A new fungal metabolite, nygerone A (1), featuring a unique 1-phenylpyridin-4(1H)-one core that had previously not been reported from any natural source, has been obtained from Aspergillus niger using a chemical epigenetics methodology.

Graphical abstract: A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

Article information

Article type
Communication
Submitted
29 Oct 2008
Accepted
01 Dec 2008
First published
11 Dec 2008

Org. Biomol. Chem., 2009,7, 435-438

A chemical epigenetics approach for engineering the in situbiosynthesis of a cryptic natural product from Aspergillus niger

J. C. Henrikson, A. R. Hoover, P. M. Joyner and R. H. Cichewicz, Org. Biomol. Chem., 2009, 7, 435 DOI: 10.1039/B819208A

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