Issue 2, 2009
From the journal:

Organic & Biomolecular Chemistry

New theophylline-activated Diels–Alderase ribozymes by molecular engineering

Markus Petermeiera  and  Andres Jäschke*a  

* Corresponding authors

a Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Im Neuenheimer Feld 364, Heidelberg, Germany
E-mail: jaeschke@uni-hd.de
Fax: +49 6221 546430
Tel: +49 6221 544851

Abstract

Allosteric ribozymes were developed by rational design and step-wise optimization. These ribozymes accelerate a Diels–Alder reaction between anthracene and maleimide derivatives. The optimized sequence is efficiently activated by theophylline under single and multiple turnover conditions and distinguishes between structurally similar effector molecules.

Graphical abstract: New theophylline-activated Diels–Alderase ribozymes by molecular engineering

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Article information

DOI
https://doi.org/10.1039/B816726E
Article type
Paper
Submitted
24 Sep 2008
Accepted
21 Oct 2008
First published
20 Nov 2008

Org. Biomol. Chem., 2009,7, 288-292

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New theophylline-activated Diels–Alderase ribozymes by molecular engineering

M. Petermeier and A. Jäschke, Org. Biomol. Chem., 2009, 7, 288 DOI: 10.1039/B816726E

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