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Issue 1, 2009
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Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

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Abstract

The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13C]-acetate confirmed that these were the precursors of the pyrrole moiety, methyl groups, and backbone of rumbrin, respectively. Label-dilution experiments with pyrrole-2-carboxylate confirmed it was a direct precursor in the biosynthesis of rumbrin. Both 3- and 4-chloropyrrolecarboxylates were also accepted as precursors in polyene production.

Graphical abstract: Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

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Publication details

The article was received on 31 Jul 2008, accepted on 24 Sep 2008 and first published on 31 Oct 2008


Article type: Paper
DOI: 10.1039/B813236D
Citation: Org. Biomol. Chem., 2009,7, 111-116
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    Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

    B. R. Clark and C. D. Murphy, Org. Biomol. Chem., 2009, 7, 111
    DOI: 10.1039/B813236D

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