Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

Tze-Sian Pui; Ajay Agarwal; Feng Ye; Zhi-Qiang Tou; Yinxi Huang; Peng Chen

doi:10.1039/B9NR00092E

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Nanoscale

Issue 1, 2009

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Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

Tze-Sian Pui , Ajay Agarwal , Feng Ye , Zhi-Qiang Tou , Yinxi Huang and Peng Chen

Nanoscale, 2009, 1, 159-163

DOI: 10.1039/B9NR00092E
Received 03 May 2009, Accepted 27 Jun 2009
First published on the web 13 Aug 2009

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Abstract
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Perfectly aligned arrays of single-crystalline silicon nanowires were fabricated using top-down CMOS-compatible techniques. We demonstrate that these nanowire devices are able to detect adipocytokines secreted by adipose cells with femtomolar sensitivity, high specificity, wide detection range, and ability for parallel monitoring. The nanowire sensors also provide a novel tool to reveal the poorly understood signaling mechanisms of these newly recognized signaling molecules, as well as their relevance in common diseases such as obesity and diabetes.

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Supplementary Info

Process diagram of nanowire fabrication; specificity ofnanowire detection; induced differentiation of 3T3-L1 cells
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Articles By

Tze-Sian Pui
Ajay Agarwal
Feng Ye
Zhi-Qiang Tou
Yinxi Huang
Peng Chen

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Nanoscale

Ultra-sensitive detection of adipocytokines with CMOS-compatible silicon nanowire arrays

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