Heterologous expression systems for polyketide synthases

Isao Fujii

doi:10.1039/B817092B

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Natural Product Reports

Issue 2, 2009

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Heterologous expression systems for polyketide synthases

Isao Fujii

Nat. Prod. Rep., 2009, 26, 155-169

DOI: 10.1039/B817092B
Received 29 Sep 2008, First published on the web 09 Dec 2008

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Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides. Their heterologous expression enables overproduction of target compounds, generation of novel analogs, and provides a basic understanding of their reaction programs. This Highlight outlines the current state of heterologous expression of type I, type II, and type III polyketide synthases of microbial and plant origins.

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Heterologous expression systems for polyketide synthases

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