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Iridium complexes of chiral diamines containing carbon and nitrogen stereocentres: synthesis, structure and evaluation as transfer hydrogenationcatalysts
School of Chemistry, University of St. Andrews, EaSTCHEM, St. Andrews, Fife, UK
E-mail: jaf14@st-andrews.ac.uk
; Fax: +44 (0)1334 463808
; Tel: +44 (0)1334 463859
b
Department of Chemistry, Washington and Lee University, Lexington, USA
E-mail: francem@wlu.edu
; Fax: +1 (0)540 458 8878
; Tel: +1 (0)540 458 8879
New J. Chem., 2009,33, 466-470
DOI:
10.1039/B812699B
Received
24 Jul 2008,
Accepted
07 Nov 2008
First published online
24 Nov 2008
Novel Rh(III) and Ir(III) complexes of a chiral diamine ligand have been synthesised and structurally characterised. Both complexes were formed as a single diastereomeric species with a single configuration at nitrogen. Ir complexes of the chiral diamine were found to be active in the asymmetric transfer hydrogenation of bulky ketones. Excellent conversions (up to 100%) and moderate enantioselectivities (up to 60%) were obtained in the asymmetric reduction of 2,2-dimethylpropiophenone.
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