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Issue 12, 2009
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Modular logical modelling of the budding yeast cell cycle

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Abstract

Systems biologists are facing the difficult challenge of modelling and analysing regulatory networks encompassing numerous and diverse components and interactions. Furthermore, available data sets are often qualitative, which complicates the definition of truly quantitative models. In order to build comprehensive and predictive models, there is clearly a need for incremental strategies, enabling the progression from relatively small to large scale models. Leaning on former models, we have defined a logical model for three regulatory modules involved in the control of the mitotic cell cycle in budding yeast, namely the core cell cycle module, the morphogenetic checkpoint, and a module controlling the exit from mitosis. Consistency with available data has been assessed through a systematic analysis of model behaviours for various genetic backgrounds and other perturbations. Next, we take advantage of compositional facilities of the logical formalism to combine these three models in order to generate a single comprehensive model involving over thirty regulatory components. The resulting logical model preserves all relevant characteristics of the original modules, while enabling the simulation of more sophisticated experiments.

Graphical abstract: Modular logical modelling of the budding yeast cell cycle

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Publication details

The article was received on 21 May 2009, accepted on 05 Jun 2009 and first published on 31 Jul 2009


Article type: Paper
DOI: 10.1039/B910101M
Citation: Mol. BioSyst., 2009,5, 1787-1796
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    Modular logical modelling of the budding yeast cell cycle

    A. Fauré, A. Naldi, F. Lopez, C. Chaouiya, A. Ciliberto and D. Thieffry, Mol. BioSyst., 2009, 5, 1787
    DOI: 10.1039/B910101M

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