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Issue 10, 2009
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Fluorine—a new element in the design of membrane-active peptides

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Abstract

Antimicrobial peptides (also known as genetically encoded peptide antibiotics) are a diverse class of short cationic amphipathic polypeptides that exhibit a broad-spectrum of antimicrobial activities by selectively disrupting the bacterial cell membrane. In this review article, we present the use of fluorinated amino acids in the design of antimicrobial peptides and other membrane-active peptides.

Graphical abstract: Fluorine—a new element in the design of membrane-active peptides

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Publication details

The article was received on 19 May 2009, accepted on 02 Jul 2009 and first published on 28 Jul 2009


Article type: Review Article
DOI: 10.1039/B909864J
Citation: Mol. BioSyst., 2009,5, 1143-1147
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    Fluorine—a new element in the design of membrane-active peptides

    E. N. G. Marsh, B. C. Buer and A. Ramamoorthy, Mol. BioSyst., 2009, 5, 1143
    DOI: 10.1039/B909864J

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