Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

Semin Lee; Alan Brown; William Ross Pitt; Alicia Perez Higueruelo; Sungsam Gong; George Richard Bickerton; Adrian Schreyer; Duangrudee Tanramluk; Alison Baylay; Tom Leon Blundell

doi:10.1039/B906402H

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Molecular BioSystems

Issue 12, 2009

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Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

Semin Lee , Alan Brown , William Ross Pitt , Alicia Perez Higueruelo , Sungsam Gong , George Richard Bickerton , Adrian Schreyer , Duangrudee Tanramluk , Alison Baylay and Tom Leon Blundell

Mol. BioSyst., 2009, 5, 1456-1472

DOI: 10.1039/B906402H
Received 31 Mar 2009, Accepted 03 Jul 2009
First published on the web 06 Aug 2009
This article is part of the collection: Computational and systems biology and Molecular BioSystems Review Articles in the “-omics sciences”

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Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach to the study of the fibroblast growth factor (FGF)-stimulated mitogen-activated protein kinase (MAPK) pathway.

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Molecular BioSystems

Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development of novel therapeutics

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