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Issue 9, 2009
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The topology of drug–target interaction networks: implicit dependence on drug properties and target families

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Abstract

The availability of interaction data between small molecule drugs and protein targets has increased substantially in recent years. Using seven different databases, we were able to assemble a total of 4767 unique interactions between 802 drugs and 480 targets, which means that on average every drug is currently acknowledged to interact with 6 targets. The application of network theory to the analysis of these data reveals an unexpectedly complex picture of drug–target interactions. The results confirm that the topology of drug–target networks depends implicitly on data completeness, drug properties, and target families. The implications for drug discovery are discussed.

Graphical abstract: The topology of drug–target interaction networks: implicit dependence on drug properties and target families

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Publication details

The article was received on 23 Mar 2009, accepted on 26 May 2009 and first published on 08 Jul 2009


Article type: Paper
DOI: 10.1039/B905821B
Citation: Mol. BioSyst., 2009,5, 1051-1057
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    The topology of drug–target interaction networks: implicit dependence on drug properties and target families

    J. Mestres, E. Gregori-Puigjané, S. Valverde and R. V. Solé, Mol. BioSyst., 2009, 5, 1051
    DOI: 10.1039/B905821B

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