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Issue 9, 2009
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Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

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Abstract

From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones were shown to be isoform-selective PKC-ζ inhibitors.

Graphical abstract: Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

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Publication details

The article was received on 18 Feb 2009, accepted on 08 Apr 2009 and first published on 08 May 2009


Article type: Communication
DOI: 10.1039/B903036K
Citation: Mol. BioSyst., 2009,5, 927-930
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    Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

    L. Yuan, J. Seo, N. S. Kang, S. Keinan, S. E. Steele, G. A. Michelotti, W. C. Wetsel, D. N. Beratan, Y. Gong, T. H. Lee and J. Hong, Mol. BioSyst., 2009, 5, 927
    DOI: 10.1039/B903036K

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