In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

Kazuto Watanabe; Mariko Harada-Shiba; Akira Suzuki; Risa Gokuden; Ryohsuke Kurihara; Yusuke Sugao; Takeshi Mori; Yoshiki Katayama; Takuro Niidome

doi:10.1039/B900880B

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Molecular BioSystems

Issue 11, 2009

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In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

Kazuto Watanabe , Mariko Harada-Shiba , Akira Suzuki , Risa Gokuden , Ryohsuke Kurihara , Yusuke Sugao , Takeshi Mori , Yoshiki Katayama and Takuro Niidome

Mol. BioSyst., 2009, 5, 1306-1310

DOI: 10.1039/B900880B
Received 30 Jan 2009, Accepted 12 Aug 2009
First published on the web 21 Aug 2009

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Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

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Kazuto Watanabe
Mariko Harada-Shiba
Akira Suzuki
Risa Gokuden
Ryohsuke Kurihara
Yusuke Sugao
Takeshi Mori
Yoshiki Katayama
Takuro Niidome

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Molecular BioSystems

In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

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