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Issue 11, 2009
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In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

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Abstract

Intravenous delivery of apolipoprotein B-specific siRNA with a sixth-generation of dendritic poly(L-lysine) (KG6) resulted in siRNA-mediated knockdown of ApoB in healthy C57BL/6 mice without hepatotoxicity, and with a significant reduction of serum low-density lipoprotein cholesterol in apolipoprotein E-deficient mice.

Graphical abstract: In vivo siRNA delivery with dendritic poly(l-lysine) for the treatment of hypercholesterolemia

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Publication details

The article was received on 30 Jan 2009, accepted on 12 Aug 2009 and first published on 21 Aug 2009


Article type: Communication
DOI: 10.1039/B900880B
Citation: Mol. BioSyst., 2009,5, 1306-1310
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    In vivo siRNA delivery with dendritic poly(L-lysine) for the treatment of hypercholesterolemia

    K. Watanabe, M. Harada-Shiba, A. Suzuki, R. Gokuden, R. Kurihara, Y. Sugao, T. Mori, Y. Katayama and T. Niidome, Mol. BioSyst., 2009, 5, 1306
    DOI: 10.1039/B900880B

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